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Project UB

Etude et estimation de la consommation totale d’électricité par calage avec ou sans réduction du nombre de variables auxiliaires. Template: The Legrand Orange Book LaTeX Template Version 1.4 (12/4/14) This template has been downloaded from: http://www.LaTeXTemplates.com Original author: Mathias Legrand (legrand.mathias@gmail.com) License: CC BY-NC-SA 3.0 (http://creativecommons.org/licenses/by-nc-sa/3.0/)

Amin Elg

Math 240 - Proof 2

This is a proof for the following claim: Prove that if n is a positive integer, then n is odd if and only if 5n+6 is odd.

Jose Delgado

Engineering Fasciculin-II to treat Alzheimer's Disease Related Symptoms

Alzheimer’s disease is characterized by death of cholinergic neurons, which secrete the neurotransmitter acetylcholine. This results in a loss of the total amount of acetylcholine circulating in neural networks. Modern drugs target acetylcholinesterase so as to inhibit its function, allowing for increased transmission of acetylcholine in cholinergic synapses. The aim is that an increase in cholinergic activity leads to an increase in cognition. However, these drugs only bind temporarily and have consequential problems that make modern AChE inhibitors of little effect. The main goal of our project is to engineer a snake toxin, fasciculin-II, capable of crossing the blood brain barrier and inhibiting acetylcholinesterase with enough affinity that it increases cholinergic transmission without yielding toxic outcomes. This fasciculin binds to the peripheral acetylcholinesterase found in neuromuscular junctions and causes rapid twitching. Fasciculin-II binds to acetylcholinesterase very tightly with the use of many charged residues and hydrophobic residues and we would like to optimize this interaction so that it may serve a therapeutic purpose in patients of AD.

Paula